Synthesis and Spectral, Electrochemical, Protein-Docking and Biological Studies of Fluoxetine Dithiocarbamate and Its Bivalent Metal Complexes

A dithiocarbamate ligand, FLXDTC, has been synthesized from fluoxetine drug along with its complexes of some bivalent metal ions such as Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Mn(II) and Cu(II). The ligand and the complexes have been characterized by various analytical and spectroscopic methods in addition to some voltammetry studies. The studies propose the formation M(FLXDTC)2 complex for all where M = Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Mn(II) and Cu(II) ions. It is also found that Cu(FLXDTC)2 takes in more CuCl2 to result in a Cu2(FLXDTC)2Cl2 kind binuclear complex with sulfur atom bridges Antimicrobial, antioxidant, antifungal, anti-malarial and antitumor capabilities have been tested for both FLXDTC and M(FLXDTC)2 complexes. Molecular docking studies on Cu(FLXDTC)2 with the intercession of EGFR protein show good antimicrobial and antifungal activities. Biological studies of manganese and nickel complexes have shown excellent antioxidant activity with IC50 values of 11.29 ± 1.85 and 11.51 ± 1.38 μM. Three different cancer cell lines, viz., MCF-7, HepG-2 and HEK 293 have been subjected to the anticancer screening for FLXDTC and it metal complexes whereby it is revealed that Cd(FLXDTC)2 has greater activity against MCF-7 (IC50 = 23.08 ± 0.12 µM), HepG-2 (IC50 = 12.30 ± 0.25 µM) whereas Zn(FLXDTC)2 exhibits good anticancer activity against MCF-7 (IC50 = 28.63 ± 1.36 µM), HepG-2 (IC50 = 19.24 ± 1.04 µM).