Electroanalytical Determination of Acetaminophen using Polymerized Carbon Nanocomposite based Sensor
2021
Abstract Acetaminophen (AC) is one of the most commonly consumed painkillers worldwide and hence its increased use leads to higher concentrations in source water, thus needful its analysis. The study of the voltammetric analysis of the AC using the fabricated sensor was presented in this article. The voltammetric sensor based on the poly asparagine modified carbon nanotube and graphene mixed paste electrode (PASMCNTMGPE) was constructed. The constructed electrode unveiled a boosted electrocatalytic activity towards the detection of the AC than the unmodified electrode through the cyclic voltammetry (CV) and differential pulse voltammetry technique (DPV). The Field emission electron microscopy (FE-SEM) was utilized to verify the morphological feature of the designed electrode. The charge transfer resistance of the designed electrode was studied by electrochemical impedance spectroscopy (EIS). Some of the factors influencing the voltammetric signal of the AC such as the number of electropolymerisation cycles and pH were optimized. The redox reaction of the AC at the PASMCNTMGPE is a pH-dependent and adsorption-controlled process. The designed electrode yielded a low detection limit (4.10 × 10−8 M) for AC. In addition, the prepared electrode demonstrated an excellent anti-fouling property, reliability, and repeatability. The PASMCNTMGPE displayed an outstanding selectivity. More importantly, the feasibility of the constructed sensor was evaluated by analyzing the AC in pharmaceutical and biological samples.
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