이황화탄소 중독자들의 노출중단 이후의 심박동수 변이

Objectives: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS₂)-poisoned subjects suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS₂-poisoned subjects participated, (2) no females participated, and (3) the CS₂-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. Methods: The study subjects comprised 122 retired workers with CS₂ poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, weight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. Results: Univariate analysis revealed that all HRV indices of CS₂-poisoned subjects were lower than those of the controls. Multiple linear regression analysis showed that CS₂ poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant (P Conclusions: This study suggests that CS₂-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.