Pemphigus Vegetans: Its Relationship to Eosinophilic Spongiosis and Favorable Response to Dapsone

• Two cases of pemphigus vegetans are presented. One, an example of the Hallopeau type of the disease, was found to have early lesions that simulated eosinophilic spongiosis clinically and histologically. The other had lesions that were largely confined to the oral mucosa and was also considered to be the Hallopeau type of the disease in a limited form. The cases of these two patients were compared with a typical case of eosinophilic spongiosis. All were controlled with dapsone therapy. ( Arch Dermatol 116:65-68, 1980)