Chromosomal basis of adenocarcinoma of the prostate

AbstractProstate cancer is the most frequent malignancy and the second leading cause of cancer deaths among males in the Western world. The clinical course of the disease is highly complex, and genetic factors underlying tumorigenesis are poorly understood. The challenge that lies ahead is to identify the important gene(s) that causes adenocarcinoma of the prostate. Chromosomal findings by cytogenetic and molecular methods, including Southern blotting, microsatellite analysis, fluorescence in situ hybridization, and comparative genomic hybridization, revealed a high frequency of chromosomal aberrations of heterogeneous nature, including: — 1, + I, —1q, +4, -6q, -7, + 7, -8, -8p, -8q, +i(8q), -9, -9p, -10, + 10, +11, -12, -13q, -16, -16q, +16, -17, +17, +17q, -18, +18, -18, +19p, +20q, +X, -Xq, — Y, and +Y. Specific chromosomal regions of alterations were 1q24–25, 2cen-q31, 5cemq23.3, 6q14–23.2, 7q22–q31, 8p12–21, 8p22, 8q24-qter, 10q22.1, 10q23–25, 11p11.2, 16q24, 17p13.1, 18q12.2, and Xq11–12. Recently, ...