Overactivation of the TGF‐β pathway confers a mesenchymal‐like phenotype and CXCR4‐dependent migratory properties to liver tumor cells

Esther Bertran,Eva Crosas-Molist,Patricia Sancho,Laia Caja,Judit López-Luque,Estanislao Navarro,Gustavo Egea,Raquel Lastra,Teresa Serrano,Emilio Ramos,Isabel Fabregat

Overactivation of the TGF‐β pathway confers a mesenchymal‐like phenotype and CXCR4‐dependent migratory properties to liver tumor cells

2013

Esther Bertran
Eva Crosas-Molist
Patricia Sancho
Laia Caja
Judit López-Luque
Estanislao Navarro
Gustavo Egea
Raquel Lastra
Teresa Serrano
Emilio Ramos
Isabel Fabregat

UNLABELLED: Transforming growth factor-beta (TGF-β) is an important regulatory suppressor factor in hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects and ...

Keywords:

Virology
Biology
Suppressor
CXCR4
Mesenchymal stem cell
Cancer research
Epithelial–mesenchymal transition
Phenotype
Transforming growth factor
Immunology
Liver tumor
Protein-Serine-Threonine Kinases
Gene silencing
Cell migration
Cytokine
Autocrine signalling
Tumor progression
Stromal cell

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