EVALUATION OF PHYSIOCHEMICAL AND ANTI-TUBERCULAR ACTIVITY OF CO-CRYSTAL OF ISONIAZID WITH METHYL PARABEN

The aim of the present research work to apply crystal engineering for the selection of API and co-former with primary amide and to investigate the preparation and characterization of co-crystal preparation. Isoniazid (INH, Pyridine-4carboxyhydrazide) is used as a first line anti-tubercular agent, in combination with other anti-tubercular drugs for the effective treatment of active diseases and also used for prevention of tuberculosis in individuals who have been exposed to active disease. The supra molecular interactions of isoniazid with carboxylic acid resulted in co-crystal based on the nature of carboxylic acid.co-crystals of (1:1 stoichiometric ratio) isoniazid with methyl paraben was reported. These prepared crystal forms I resolve the poor micrometric problems of isoniazid and shows improved flow and compa ction property than isoniazid. From the anti-tubercular test performed it has confirmed that the co-crystal forms of methyl paraben and INH (S9) had shown increased activity compared to the pure drug .