A versatile to conjugated hydroxy (E, Z, E, E)-tetraenoic acids: highly chemo- and stereoselective synthesis of lipoxin B4

Abstract A highly convergent total stereocontrolled synthesis of lipoxin B 4 is described by an efficient Pd-catalyzed coupling reaction of two easily accessible chiral synthons 2 and 3 without any protection-deprotection sequence of the alcohol functions.