Acoustic cavitation assisted hot melt mixing technique for solid lipid nanoparticles formulation, characterization, and controlled delivery of poorly water soluble drugs

Abstract The motive of the present study was to enhance the bioavailability of poorly water soluble active pharmaceutical ingredients (APIs) through by making solid lipid nanoparticles (SLNs) using acoustic cavitation assisted hot melt mixing method. Here, we investigated the efficacy of this technique for preparation of SLNs loaded with different drugs. To achieve the high entrapment efficiency and drug loading, the effect of the ratio of lipid to emulsifier on SLNs’ properties and their performance were studied. The solid state of drugs in formulated solid lipid nanoparticles was characterize using several advanced characterization techniques. As the emulsifier concentration increases, decreased in particle size was observed. We achieved the high entrapment efficiency (more than 80%) and drug loading (4.9–5.4%) at optimum lipid to emulsifier ratio 7:4 and 10% (w/w) drug concentration. The formulated drug loaded solid lipid nanoparticles showed good biocompatibility against Raw 264.7 cells and nearly 100% drug was release at end of day-3. It is concluded that acoustic cavitation assisted hot melt mixing method suitable for formulation of SLNs. Hence, it is evident that the better performance of formulated SLNs of poorly water soluble APIs loaded tristearin nanoparticles in vitro and could be developed further for clinical studies.