Содержание АТФ и активность над(ф)-зависимых дегидрогеназ в лимфоцитах при им муно дефицит-ассоциированных заболеваниях у пришлых жителей Эвенкии

108 newcomers of Evenkia were examined to study the peculiarities of interconnection between ATP concentration and NAD(P)-dependent dehydrogenases activity in blood lymphocytes in the immunodeficiency-associate diseases. The hyporeactive and hyperreactive disturbances of functional state of immune system were found. The ATP concentration and NAD(P)-dependent dehydrogenases activity were determined in blood lymphocytes by bioluminescent methods. It was revealed, that ATP content was increased against the control in blood lymphocytes at true allergy. The intracellular ATP level at true allergy depended on intensity of flexible and power processes, which were characteristic of functionally activated cells, whereas it was determined by glycolysis and 2-oxoglutarate dehydrogenase activities at the hyporeactive secondary immunodeficiency disorders. The ATP concentration dependence on some enzyme activities has been proved at immunodeficiency-associated diseases that suggests the raised probability of energetic homeostasis failure in immune system cells in case of immune response development which can cause functional activity disturbance of lymphocytes.