Development of a Scalable Method for Manufacturing the Central Core of CD73 Inhibitor AB680

Jeremy Fournier,Xuelei Yan,Anh Tran,Grange Rebecca Louise,Steven D. Jacob,Jarosław Kalisiak,Kenneth V. Lawson,Eric F. Connor,Manmohan Reddy Leleti,Jay P. Powers

Development of a Scalable Method for Manufacturing the Central Core of CD73 Inhibitor AB680

2020

Jeremy Fournier
Xuelei Yan
Anh Tran
Grange Rebecca Louise
Steven D. Jacob
Jarosław Kalisiak
Kenneth V. Lawson
Eric F. Connor
Manmohan Reddy Leleti
Jay P. Powers

AB680 is a highly potent CD73 small molecule inhibitor discovered and developed by Arcus Biosciences, currently in clinical trials for the treatment of pancreatic cancer. Here, we report the develo...

Keywords:

Clinical trial
Cancer research
Small molecule
Pancreatic cancer
Medicine

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