TnI and IL-18 levels are associated with prognosis of sepsis

Aim To evaluate the diagnostic value of interleukin-18 (IL-18) and troponin (TnI) in sepsis. Methods This retrospective analysis included 117 patients with sepsis (patient group) and 92 subjects who attended regular physical examinations (control group). We compared IL-18 and TnI expressions before treatment (T1) and on day 5 (T2), day 10 (T3) and day 15 (T4) of treatment. Acute Physiology and Chronic Health Evaluation II (APACHE II) guidelines were used to analyse the correlation between IL-18, TnI and APACHE II scores. Results At T1, T2, T3 and T4, the IL-18 and TnI levels were all higher in the patient group than in the control group (p Conclusions Monitoring TnI and IL-18 levels can effectively evaluate the severity and recovery of patients with sepsis.