SYNTHESIS AND ENZYMATIC STABILITY OF ACYCLIC THYMIDINE DIMER ANALOGUES HAVING A CONSTRAINED ANTI-GLYCOSIDIC CONFORMATION

Abstract Our interest to design a novel class of antisense oligonucleotides has lead us to prepare acyclic thymidine dimer analogues having an unique constrained antiglycosidic conformation. These dimer analogues showed remarkable resistance to nuclease degradation, such as Nuclease S1, Bovine Spleen Phosphodiesterase, and Snake Venom Phosphodiesterase.