Negative effects of chronic kidney failure on lung function and functional capacity Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Abstract Objective: To evaluate lung function and functional capacity in patients with chronic kidney failure (CKF) undergoing dialysis and in patients after kidney transplant. Methods: Seventy-two participants were evaluated: 32 patients with CKF on dialysis (DG) for at least six months, ten patients who had kidney transplants (TG) at least six months earlier, and 30 healthy subjects as a control group (CG). all groups were evaluated using spirometry, with maximum inspiratory pressure (mIP) and maximum expiratory pressure (mEP), and using the six-minute walking test (6mWT). The SPSS 12.0 software was used for statistical analysis, with a minimum significance level of α<0.05. Results: There was a decreased lung function in the DG for FVC, FEV1, mVV, VC, mIP and mEP, and decreased FEV1 and mVV in the TG compared to the CG (one-way aNOVa/Fisher’s post-hoc; p<0.01). There was also an association (chi-square) between decreased mIP and belonging to the DG (ג=0.5, p<0.001), between lower performance in the 6mWT for the DG and TG (p<0.01) compared to the CG (one-way aNOVa/Fisher’s post-hoc), and between mIP and mEP (Pearson’s coefficient; r=0.752; p<0.01). Conclusions: Patients with CKF undergoing dialysis showed impaired functional capacity and lung function that were not completely reverted in the kidney transplant patients. Key words: dialysis; kidney transplant; spirometry; respiratory muscles; functional capacity.