DNA demethylation in hormone-induced transcriptional derepression

Gene regulation is known to be affected by epigenetic modifications at the histone level in response to extracellular signals; however, the effect of modifications at the DNA level, and especially active DNA demethylation, are not well understood. Here, DNA methylation/demethylation is found to be hormonally switched in order to control the transcription of the cytochrome p450 27B1 gene.