119 RELATIONSHIPS AMONG AND DISCRIMINATORY ABILITY OF INFLAMMATORY MEDIATORS IN SERUM AND SYNOVIAL FLUID IN A CROSS-SECTIONAL OSTEOARTHRITIS COHORT

from 52 joints of 16 normal Thoroughbred horses, collected bilaterally from carpal joints of 10 horses (n=40), and MP joints of 6 horses (n=12). A previously validated commercially available immunoassay was used to determine equine SF BAP concentrations. Results: SF BAP concentrations from the carpal joints of normal horses were 2.2 times higher than SF BAP concentrations from the MP joints of normal horses (P<0.05; Figure 1). SF BAP concentrations from OC injured carpal joints were 2.7 times higher than concentrations from OC injured MP joints (P<0.001). In addition, SF BAP concentrations from the OC injured carpal joints were significantly higher than from normal carpal joints (P<0.001). However, there was no significant difference between SF BAP concentrations from normal and OC injured MP joints. When combining the OC injured carpal and MP samples, SF BAP concentrations were positively correlated to the joint that was affected (R=0.554, P=0.0001).