Los aminoácidos como marcadores bioquímicos en las neuropatías ópticas epidémica y endémica
1998
Se estudio el patron de aminoacidos en suero y liquido cefalorraquideo (LCR) de 12 y 8 pacientes respectivamente, con neuropatia optica epidemica diagnosticada entre 1995-1997 (periodo endemico). Ademas se estudio el LCR de 16 pacientes diagnosticados durante la epidemia (1992). El analisis de aminoacidos en suero y LCR se llevo a cabo por cromatografia liquida de alta resolucion con deteccion fluorescente, previa derivatizacion con aldehido ortoftalico. Al igual que en el estudio anterior, no se observaron deficiencias importantes de los aminoacidos esenciales en el suero de los pacientes estudiados, aunque se encontraron concentraciones menores de treonina, acido aspartico y taurina en el suero de los pacientes con neuropatia optica epidemica diagnosticada en el periodo endemico. La taurina desempena una funcion importante en la estructura y funcion de los fotorreceptores de la retina. En el hombre no es sintetizada en las cantidades necesarias, por lo que debe ser suplida en la dieta. Por encontrarse solamente en alimentos de origen animal, consideramos que la deficiencia de taurina podria ser un factor contribuyente al desarrollo de la neuritis optica epidemica en nuestros pacientes. Se analizaron ademas muestras de LCR en los periodos epidemico y endemico, se observo aumento de acido glutamico y aspartico en el periodo epidemico y de acido glutamico durante la endemia. La presencia de un exceso de aminoacidos excitotoxicos en el LCR apoya los estudios neurocognitivos previos que sugerian afeccion del sistema nervioso central en estos pacientes.(AU) It was studied the aminoacids pattern in serum and cerebrospinal fluid of 12 and 8 patients, respectively, suffering from optic epidemic neuropathy diagnosed between 1995 and 1997 (endemic period). The cerebrospinal fluid of 16 patients diagnosed during the epidemic (1992) was also studied. The analysis of aminoacids in serum and cerebrospinal fluid was made by high resolution liquid chromatography with fluorescent detection, previous derivation with orthofthallic aldehyde. As in the previous study, no important deficiencies of the essential aminoacids were observed in the serum of the studied patients. Lower concentrations of threonine, aspartic acid and taurine were found in the serum of patients with epidemic optic neuropathy diagnosed in the endemic period. Taurine plays an important role in the structure and function of photoreceptors of the retina. It is synthesized in the necessary amounts in man, so it must be supplied in the diet. As it is only present in food of animal origin, it is considered that the deficiency of taurine may contribute to the development of optic epidemic neuritis in our patients. Samples of cerebrospinal fluid were analyzed during the epidemic and endemic periods and it was observed an increase of the glutamic and aspartic acid in the epidemic period and of glutamic acid during the endemia. The excess of excitotoxic aminoacids in the cerebrospinal fluid supports the previous neurocognitive studies that suggested the affection of the central nervous system in these patients.(AU)
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
11
References
0
Citations
NaN
KQI