REVITALIZATION OF ANTIOXIDANT ENZYMES BY RED GRAPE SEED EXTRACT (RGSE) DUE TO D-GALACTOSE INDUCED CHANGES ON ALZHEIMER’S DISEASE (AD) IN MALE ALBINO RATS

Neurodegenerative and terminal disease was first discovered by German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was named after him. Generally, it is diagnosed in people over 65 years of age. In this study, the protective role of grape seed extract against D-Galactose dose-induced neural toxicity has been evaluated. The present study was carried out on the male albino rat, Age matched rats were be divided into 4 groups of six in each group and treated as follows: Group-I.Control (C) rats received 0.9% saline. Group-II. Rats treated with intraperitonealy (IP) administered with D-Gal (120 mg/kg body weight) up to end of the experiment (1st day to 90th day).Group-III. Rats treated orally administered with Red grape seed (GSE) ethanol extract (100mg/kg body weight) for 60 days. Group-IV. Rats were treated with intraperitonealy injected with D-Gal (120 mg/kg body weight) once daily for first 30 days. From 31stday onwards rats were…