Taming the reactivity of Phosphiranium salts: Site-selective C-centered-Ring Opening for Direct Synthesis of Phosphinoethylamines.

This work documents advances in the field of phosphorus chemistry, by revealing the synthetic utility of the heretofore under-utilized quaternary phosphiranium salts ( QPrS ) as 3-chain atoms electrophilic building blocks. Notably, the control of their challenging C-centered electrophilicity is disclosed with as proof of concept an expedient synthesis of tertiary beta-anilino phosphines.