Original Article Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia

Background: Chromosomal translocations are usually analyzed as a single entity, and are associated with a poor outcome in chronic lymphocytic leukemia. Translocations involving immunoglobulin genes are recurrent, but uncommon ( 4 (p 4, frequent trisomy 12, no ATM and 6q deletions, and a mutated IGHV status. Compared to BCL3-CLLs, BCL2- CLLs are much less aggressive; indicating that identifying individual translocations and cytogenetic partners would allow improved patient stratification.