Ion-Exchange Route to Au–CuxOS Yolk–Shell Nanostructures with Porous Shells and Their Ultrasensitive H2O2 Detection

In this letter, Au–CuxOS yolk–shell nanostructures with porous shell are prepared through a facile ion exchange route from Au@Cu2O core–shell nanostructures. The as-prepared yolk–shell nanostructures exhibit ultrasensitive enzyme-free detection of H2O2 molecules with higher sensitivity (50.41 μA μM–1) and lower detection limit (0.01 μM) as well with excellent anti-interference capacity in comparison with both hollow CuxOS nanospheres and Au nanoparticles. Therefore, the obtained Au–CuxOS yolk–shell nanostructures have potential application in ultralow concentration enzyme-free H2O2 detection for biomedicine diagnosis.