Padronização de parâmetros ecocardiográficos de cães da raça Golden Retriever clinicamente sadios

The Duchenne's muscular dystrophy (DMD) in humans is a recessive X-linked neuromuscular disease, caused either by the absence or dysfunction of the dystrophin. Clinically it is characterized by severe alteration in the skeletal musculature, resulting in precocious death of the affected patient. In Golden Retriever dogs, the mutation that determines the muscular dystrophy occurs spontaneously and the extensive homology among the pathogenesis of DMD and of Golden Retriever muscular dystrophy allows to qualify the dog as the main substitute of humans in the clinical tests of new therapies. The deficient myocardium in dystrophin is more vulnerable to the pressure overload, and the patients with DMD can develop dilated cardiomyopathy as well as arterial hypertension; in echocardiography, diastolic function abnormalities are verified and systolic inadequacy can be observed in some old patients. In the present study, 41 healthy Golden Retriever dogs were evaluated by echocardiographic exam with the purpose to obtain parameters for the standardization of these cardiovascular characteristics in the refered breed, what hereafter can be used as reference in the identification of bearer or affected dogs by muscular dystrophy.