A Reprogrammable Low Power Closed-Loop Optogenetic Platform for Freely Moving Animals

In this paper, we present a reprogrammable low power optogenetic based platform for closed-loop processing, which aims on neural abnormal activity invention such as epilepsy. The system is comprised of an embedded control system, and a custom designed ASIC chip for electrical recording and optical stimulation. Compared to current technologies, developed technology is not only show ultra-low power consumptions but also displays strong computational flexibility. A power cycling technique was implemented, which reduces the average power consumption of the system down to 2.93 mA at recording frequency 50Hz (equal to ASIC level). This allows a system lifetime up to 56 hours with a single Lithium-Polymer battery (165mAh). Then a three-stage closed-loop processing scheme is employed to foster a Brain-machine Interface (BMI) tool box, which allows the system meets various biomedical application requirements. By using in-vivo epilepsy neural data, our system demonstrates the capability for realtime intervention of abnormal activities. Hence, the developed technology shows great potential for both rodent behavior control based and implantable electronics applications such as chest units.