Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists

Hiroko Masamune,Ronald Breslow,John B. Cheng,Maryrose J. Conklyn,James Frederick Eggler,Anthony Marfat,Lawrence S. Melvin,Joann S. Pillar,John T. Shirley,Henry J. Showell,Jeanene E. Tickner

Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists

1995

Hiroko Masamune
Ronald Breslow
John B. Cheng
Maryrose J. Conklyn
James Frederick Eggler
Anthony Marfat
Lawrence S. Melvin
Joann S. Pillar
John T. Shirley
Henry J. Showell
Jeanene E. Tickner

Abstract The development of novel LTB 4 antagonists from a class of quinolylmethyl LTD 4 antagonists is described. These α-methyl quinolylmethyl chromanols were found to have good vitro activity.

Keywords:

Organic chemistry
Quinoline
Chemistry
In vitro
Biochemistry

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