A Concise Stereoselective Total Synthesis of Synargentolide A from 3,4,6-Tri-O-acetyl-d-glucal

A short and highly stereoselective synthesis of the naturallyoccurring, α,β-unsaturated lactone synargentolideA is described from the chiral starting material 3,4,6-tri- O-acetyl- D-glucal. Keysteps of the synthesis are lactol opening, Brown's asymmetric allylation,and a ring-closing metathesis (RCM) reaction.