Relationship of interferon-γ-inducible protein-10 kDa with viral response in patients with various heterogeneities of hepatitis C virus genotype-4

Results Patients with SVR had lower pretreatment IP-10 levels (462.4±282.7 vs. 840.1±490.6 pg/ml; P = 0.002), but the levels were not significantly different in those with a rapid (P = 0.245) or an early viral response (P = 0.221). IP-10 levels were similar across all subtypes. The pretreatment level was significantly lower in subtype 4d patients with SVR (465.9±349.1) compared with non-SVR patients (904.9±532.1; P < 0.001), but not when compared with genotype 4a patients (564.7±288.9 vs. 658.6±374.9, respectively; P = 0.330). IP-10 levels [odds ratio (OR), 0.998; 95% confidence interval (CI): 0.996–0.999; P = 0.006], low viremia (OR, 8.852; 95% CI: 1.244–63.03; P = 0.029), and early viral response (OR, 4.162; 95% CI: 1.023–16.94; P = 0.046) were independent predictors of SVR. Receiver operating characteristic curve analysis identified a threshold IP-10 level of 359 pg/ml (area under receiver operating characteristic curve, 0.737; sensitivity, 81.8%; specificity, 45.2; positive predictive value, 43.9%; negative predictive value, 82.6%) for SVR.