Timing of low bone mineral density and predictors of bone mineral density trajectory in children on long-term warfarin: a longitudinal study

Summary We studied bone mineral density (BMD) of children exposed to long-term warfarin. BMD Z-scores ≤ −2.0 were estimated to occur in less than one fifth of the patients after 10 years of warfarin exposure, and BMI and growth hormone deficiency predicted BMD changes over time. These predictors can help identify high-risk patients.