2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors.

Patricia Imbach,Hans-Georg Capraro,Pascal Furet,Helmut Mett,Thomas Meyer,Juerg Zimmermann

2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors.

2010

Patricia Imbach
Hans-Georg Capraro
Pascal Furet
Helmut Mett
Thomas Meyer
Juerg Zimmermann

Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.

Keywords:

Chemistry
Organic chemistry
Purine metabolism

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