TACE (ADAM17) inhibits Schwann cell myelination

Rosa La Marca,Federica Cerri,Keisuke Horiuchi,Angela Bachi,M. Laura Feltri,Lawrence Wrabetz,Carl P. Blobel,Angelo Quattrini,James L. Salzer,Carla Taveggia

TACE (ADAM17) inhibits Schwann cell myelination

2011

Rosa La Marca
Federica Cerri
Keisuke Horiuchi
Angela Bachi
M. Laura Feltri
Lawrence Wrabetz
Carl P. Blobel
Angelo Quattrini
James L. Salzer
Carla Taveggia

The authors report that TACE, the tumor necrosis factor-α–converting enzyme, regulates PNS myelination by affecting neuregulin-1 type III activity. Mice lacking TACE in motor neurons show hypermyelination.

Keywords:

Neuregulin 1
Neuroscience
Tumor necrosis factor alpha
Myelin basic protein
Epidermal growth factor
Motor neuron
Peripheral nervous system
Myelin
Schwann cell
Biology
ascorbic acid
Amyloid precursor protein secretase
Signal transduction

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