Correlation of cognitive symptoms with cognitive performance among brain cancer patients after radiation therapy.

2084 Background: Cognitive symptoms can occur among cancer patients, though the incidence and severity vary across cancer type, location, treatment and time. Some have argued that subjective cognitive symptoms reflect patients' mood or fatigue more than objective cognitive functioning per se and there are studies showing no correlation between complaints and performance. Methods: The present study describes the correlations at baseline between subjective cognitive symptoms (FACT-Brain symptoms subscale), fatigue (FACT-Fatigue) and mood (Profile of Mood States) and objective cognitive performance (Controlled Oral Word Association Test, Hopkins Verbal Learning Test-Revised, Digit Span Test, Trail Making Test, Grooved Pegboard and summary Cognitive Composite Score [CCS]), among 82 brain cancer survivors who are ≥ 6 months post partial or whole brain irradiation participating in a phase III clinical trial of an acetylcholinesterase inhibitor, donepezil. Results: The sample (mean age = 52 yrs.; 50% female; 83%...