Humanized anti-Factor D antibodies uses thereof

An anti-Factor D comprising a variable domain of light chain having at least 90% identity of amino acid sequence with the amino acid sequence of SEQ ID NO: 7 and a variable domain of heavy chain having at least 90% identity of amino acid sequence the amino acid sequence of SEQ ID NO: 19, wherein (i) the light chain variable domain comprises HVR-1 comprising ITSTDIDDDMN (SEQ ID NO: 30), HVR 2 comprising GGNTLRP (SEQ ID NO: 35) and HVR-3 comprising LQSDSLPYT (SEQ ID NO: 38); and (ii) the variable heavy chain domain comprises HVR-1 comprising GYTFTNYGMN (SEQ ID NO: 39), HVR-2 comprising WINTYTGETTYADDFKG (SEQ ID NO: 40) and HVR-3 comprising EGGVNN (SEQ ID NO: 41); and wherein the amino acid at position 1 of the heavy chain variable domain is E.