The Effect of Repeated intramuscular Gonadotrophin-Releasing Hormone Injections on Luteinizing Hormone, Follicle-Stimulating Hormone, Testosterone, Oestrogens, Dehydroepiandrosterone and Dehydro-epiandrosterone Sulfate in Normal Men

The endocrine response to three daily intramuscular injections of 500 μg LH-RH was measured in 9 normal men during a period of 3 days. A marked but declining response in LH was seen in addition to a significant increase in the serum concentration of FSH, testosterone, oestradiol and the urinary excretion of oestrogenic substances. No change could be demonstrated in the DHA, DHAS or cortisol secretion which confirms our previous results of a direct effect of clomiphene on adrenal steroidogenesis.