Abstract 763: Human Cardiac Beta1-Adrenergic Receptors Are Desensitized By Receptor-Mediated Activation Of Phosphatidylinositol-3 Kinase and Phosphodiesterase-4

Background: Cardiac β-adrenergic receptors (β-ARs) couple to the stimulatory G-protein (Gs), activating adenylyl cyclase to produce cAMP and increase force of contraction. Animal models suggested a...