Standardization Of Organ Specific Bremsstrahlung Imaging Using Whole Body Phantom

In view of a large number of therapeutic applications currently in practice using beta emitting radionuclides including radiosynovectomy, infusional brachytherapy and radiolabelled monoclonal antibodies, it has become increasingly important to explore the possibility of using bremsstrahlung images for quantification and delineation of leakage and retention pattern. The present study relates to standardization the bremsstrahlung imaging for 90Y and 32P by using whole body phantom containing cavities for organs, such as liver, spleen and kidneys. Various levels of activity ranging from 47 MBq to 85 MBq, both for and 32P, were used for standardization and acquisition of bremmstrahlung images using medium energy (ME) as well as low energy all-purpose (LEAP) collimator on a gamma camera. The bremsstrahlung images using ME collimator were found to depict reasonable resolution, though the sensitivity was shown to have been 'compromised. Bremsstrahlung images of incorporated beta emitting radionuclides could prove to be an effective tool for detection, localization as well as dosimetric calculations.