histiocytic lymphoma cells. ester-mediated differentiation of U-937 human gene transcription during phorbol Plasminogen activator inhibitor 2: regulation of

and reached a maximum (50-fold, as determined bydensitometry) after 8 h, returning to near base-line levelsafter 48 h. Fromthese results, it is likely that the effect ofPMAon PAI-2 biosynthesis is mainly due to an increasedtranscription rate ofthe PAI-2gene. Asacontrol, the effectofPMAon the transcription ofthe c-fos and c-myc proto-