UNDERSTANDING THE ANTIHYPERGLYCEMIC AGENTS OF THIAZOLIDINEDIONES ANALOGUES USING QUANTITATIVE STRUCTERE ACTIVITY RELATIONSHIP (QSAR) MODELS

Quantitative Structure Activity Relationship (QSAR) is a useful tool to establish quantitative relationship between various physico-chemical properties and biological activities of compounds. The present studies have been carried out on series of 5-(4'-alkoxy benzyl)-2,4thiazolidinediones derivatives, which are a class of synthetic antihyperglycemic (anti-diabetic) drugs exerting action upon activation of the peroxisome proliferators-activated receptor-γ ( PPAR-γ). The 68 compounds with similar array of biological activities were selected for QSAR model and divided into 53 training set and 15 test set. On performing multiple linear regression (MLR), the training set showed high correlation (r=0.91) of significance. The model study indicated that thermodynamic, topological descriptors interplay important role with PPAR-γ receptor.