Barriers to managing COVID-19 pandemic: Attitude towards vaccination and implications for public health

Background: In order to achieve long-term optimum public health response, herd immunity is required, and this may happen if general populations willingly offered the COVID- 19 vaccine The current study aimed to explore the attitudes toward COVID-19 vaccine, and to outline the common barriers interfering with vaccination among Egyptian population A cross-sectional study has been carried out among 1282 participants utilizing a self-administered questionnaire Results: Negative attitude was associated with low trust in the capability of the country instructions to combat COVID-19 (OR=5 97, CI95%: 3 37-10 57), unsatisfactory knowledge (OR=15 73 CI95%: 9 54-25 92), being worried about adverse effects (OR=2 97, CI95%: 1 96-4 52), being not committed to protection measures like PPE, HH and social isolation (OR=2 16, CI95%: 1 42-3 25), not working (OR=3 04, CI95%: 2 11-4 36), low education (OR=10 12, CI95%: 7 11-14 40), don't know deep experienced trials of vaccines (OR=1 76, CI95%: 1 45-2 13), being female (OR=3 09, CI95%: 2 17-4 39), increase age (OR=1 03, CI95%: 1 01-1 06) and depression symptoms (OR=1 64, CI95%: 1 12-2 41) Conclusion: The main barriers of negative attitude toward vaccine include worrying about vaccine side effects, poor knowledge regarding COVID-19 and mistrusting the country's ability to combat it