Methylene-bis-phosphonic acid derivatives and a method of their synthesis

FIELD: organic chemistry. SUBSTANCE: products: derivatives of methylene-bis-phosphonic acids of the formula (I) where: R 1 -R 4 - hydrogen or (C 1 -C 10 )-alkyl and at least one of groups R 1 -R 4 means hydrogen and at least one of these groups does not mean hydrogen; Q 1 - hydrogen, hydroxyl; Q 2 - the group y-x-(C) n R′R″ where y - free or substituted phenyl or pyridinyl, pyrimidinyl or piperidinyl; x - simple bond, -S- or -NH-group; n = 0-6; R' and R'' - hydrogen or (C 1 -C 4 )-alkyl, or their pharmaceutically acceptable salts. Reagent 1: methylene-bis-phosphonic acid tetraester that is hydrolyzed selectively to triester, diester and monoester of methylene-bis-phosphonic acid. Reaction conditions: hydrolysis is carried out with both acid and alkali at 10-150 C. Synthesized compounds were used in medicine for treatment of disorders associated with pyrophosphate function in organism. EFFECT: improved method of synthesis. 4 cl, 1 tbl