Association between EGFR gene mutations and clinical and pathological characteristics of lung adenocarcinoma in patients of the South of Russia.

e18534 Background: EGFR gene mutations are an effective marker for targeted therapy of lung cancer. EGFR plays an important role in proliferation of epithelial cells. EGFR overexpression is detected in many tumors, including 60-70% of small cell lung cancer (SCLC) cases. EGFR mutations are observed in approximately 10% of the European population and in 30-50% of the Asian population. The purpose of this study was to analyze polymorphism of 29 somatic mutations of EGFR (including T790M, exon 19 deletions, L858R, L861Q, G719X, S768I, exon 20 insertions) in tissues of lung adenocarcinoma in patients of the South of Russia, as well as to detect the connection between the found mutations and clinical and pathological characteristics of patients. Methods: We analyzed distribution of mutations depending on sex, age, smoking status, tumor differentiation and stage, clinical picture of the disease and treatment of patients with lung adenocarcinoma in the South of Russia. 278 patients (174 men, 104 women) aged 29-7...