Modulating the immune response with liposomal delivery

Abstract Lipid-based nanoparticles (LNPs) provide a platform for drug, gene, and vaccine delivery with clinical applicability to treat a variety of diseases. As advances in drug development and immune mechanisms of disease continue to evolve, LNPs are positioned to have a profound impact on the future of immunomodulatory therapeutics. This chapter offers an overview of the principles of liposomal therapeutics, and the immune system while highlighting the clinically relevant liposomal therapeutics focused on small-molecule drugs, genes, and vaccines. Using the current state of the field of liposomal therapeutics, and the lessons learned from these preclinical and clinical studies, we will be able to pave the way for future advances in clinical liposomal immunomodulation.