Efficient Synthesis of 2,4,5-Trisubstituted 2,5-Chiral Tetrahydropyridines Using a One-Pot Asymmetric Azaelectrocyclization Protocol.
2009
The stereocontrolled synthetic procedure for the preparation of 2,4,5-trisubstituted 2,5-chiral 1,2,5,6-tetrahydropyridines was established using a one-pot asymmetric azaelectrocyclization protocol; the generality of this protocol was demonstrated by synthesizing the title compounds with various aryl and alkenyl substituents at the C-2 position.
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