Neuropeptides in the Central Regulation of Blood Pressure

During the last few years, the possible role of neuronal peptides in the central baroreceptor regulatory mechanism has been the subject of considerable attention. Increasing evidence suggests that this mechanism could be partly mediated or controlled by neuropeptides, which are present in nerves, brain areas, and pathways that are known to be involved in cardiovascular regulation. Apart from their neurotransmitter mode of action, certain peptides — vasopressin and angiotensin — could also act as neurohormones; that is, they are released into the cerebrospinal fluid or the blood vessels. Central administration of many neuropeptides alters blood pressure and heart rate [1–8].