Endometrial Stromal Sarcoma: Analysis of Treatment Failures and Survival

Abstract The objective of this retrospective multicenter study was to assess the rates, times, and sites of recurrences of 26 patients with low-grade endometrial stromal sarcomas (ESS) ( P = 0.0001). By log-rank test the disease-free survival of high-grade ESS patients was related to stage ( P = 0.0466) and mitotic count ( P = 0.0014), but not to age. Cox model showed that mitotic count was the only independent prognostic variable for high-grade ESS ( P = 0.006). In conclusion, low-grade and high-grade ESS have a completely different biological aggressiveness and clinical behavior.