EFEK PENTA PEPTIDA (Trp-Phe-Ile-Leu-Lys) DAN SUSU KEDELAI FERMENTASI STERIL TERHADAP PROFIL LIPID TIKUS SPRAGUE DAWLEY HIPERKOLESTEROLEMIA

Background: Increased level of total cholesterol and Low Density Lipoprotein (LDL) are risk factors for the incidence of cardiovascular disease. It is estimated that in 2020 cardiovascular disease will become the major cause of death worldwide. Some studies show that soybean protein is hypocholesterolimic that is good either for humans or animals. Soybean milk as product of soybean is presumed to have hypocholesterolimic effect from biogenic activities of soybean protein. Peptides (Trp-Phe-lle-Leu-Lys) are produced by steril fermented soybean milk that is able to bind cholesterol in vitro. The capacity to bind cholesterol in vitro enables peptides to minimize cholesterol in vitro. Objective: To identify the effect of penta peptide supllementation to the lipid profile of hypercholesterolimic Sprague Dawley rats. Method: As many as 48 male Sprague Dawley rats of 2-3 months and + 200 g weight were used as experiment animals in the study. There were three experiment interventions. Firstly, during adaptation period the mice were given standard feeding within a week