Polypeptides coagulation factor X activation properties modified

A variant of recombinant factor X modified biologically active in a modificacionconsiste in an insertion of an additional cleavage site for a protease, and wherein the site escisionadicional is inserted between Ile235 and Val236 or between Val236 and Gly237 or between Gly237 and Gly238 in the heavy chain delfactor X and wherein deletions are excluded in the peptide sequence of factor X activation - activated proteases of maneraque naturally factor X, are no longer able to cleave and activate said variant delfactor X.