Species twin screw isatin synthesis and furan derivatives having antimicrobial activity and application

The present invention discloses a double screw having isatin species furan derivatives and synthetic method and antimicrobial activity, of formula isatin bis spiro compounds such as furan derivatives of the formula (I), wherein R is selected from hydrogen, benzyl , C ~ C alkyl group, an allyl group; R & lt selected from hydrogen, methyl, chloro; R & lt selected from hydrogen, a benzyl group, C ~ C alkyl group, an allyl group; R & lt selected from hydrogen, methyl, chlorine. The double-spiro isatin furan derivatives having good antibacterial effect, can be used as a seed of a potential antibacterial agent.