Механизмы повреждения эритроцитов при токсическом действии метгемоглобинобразователей

Structural properties of lipid component of erythrocyte membrane of Wistar rats with methemoglobinemia were investigated after one injection of sodium nitrite and phenylhydrazin chloride in DL50 dose. It was shown that in methemoglobinemia cholesterol, lysophosphatidylcholine, sphingomyelin, phosphatidylserine levels are increased and phosphatidylcholine and phosphatidyletanolamine levels are decreased, and an increase of microviscousity of erythrocyte membrane lipid matrix was elevat-ed. The degree of the elucidated changes depends on a xenobiotic and a time of methemoglobinemia period.