Lipid peroxidation as a mechanism for the regulation of platelet aggregation activity

: The paper deals with the role of free radical lipid oxidation in the mechanisms of platelet activation. The findings suggest that lipid peroxidation metabolites (primary and secondary) are able to produce regulatory effects mediated by membrane arrangement on platelet aggregatory properties. At the same time the higher levels of conjugated dienes can induce platelet aggregation in unstable angina pectoris. This expands the current concepts of the mechanisms of abnormal platelet activation and allows it to be classified as a particular system.