Crystallization and preliminary X‐ray diffraction studies of human angiostatin
2002
Angiostatin is an inhibitor of angiogenesis, the process by which new blood vessels are formed from pre-existing ones. The fact that tumor growth and metastasis dissemination are angiogenesis-dependent processes has awakened interest in angiogenesis inhibitors as anticancer treatment drugs. Angiostatin, a potent angiogenesis inhibitor, is currently in phase I clinical trials. Human angiostatin containing the first three kringle domains of plasminogen (K1-3) has been crystallized and high-resolution data were collected. The crystals belong to the P41212 space group, with unit-cell parameters a = b = 56.94, c = 192.97 A. A data set to a resolution of 1.75 A with an overall Rmerge and I/σ(I) of 7% and 19.5, respectively, was obtained.
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