GENE MUTATIONS BRCA I AND BRCA II WITH OVARIAN CANCER - THE URGENT ISSUE OF PREDICTIVE AND PREVENTIVE MEDICINE (REVIEW OF LITERATURE)

The paper deals with the problem of hereditary and sporadic ovarian cancer (OC) as well as with the impact of suppressor genes of tumor BRCA 1 and BRCA 2 and risk or clinical features of hereditary cancers today. Despite the fact that today a variety of polymorphisms in genes BRCA 1 and BRCA 2 have been identified, their clinical significance in OC has not been highlighted enough. Furthemore, the results of several studies substantiate the necessity and availability of detecting polymorphisms in genes BRCA 1 and BRCA 2 as the risk factors and molecular diagnostic markers for ovarian cancer.